Head of Team: Emmanuelle De, Professor, University of Rouen Normandy

The BRICS Team research focuses on bacterial interactions with surfaces (biotic and abiotic) and on resistance mechanisms mobilized by microorganisms, especially when the microorganisms are organized in biofilm mode. The team studies two fields: bacteria and material.

Regarding bacteria, the team aims to identify molecular determinants (proteins, polysaccharides, lipids) involved in biofilm architecture or in microorganisms’ interactions with surfaces, and those responsible for antibiotic microbial resistance. The team uses proteomic approaches (whole and/or membrane proteome, lipidome) but also characterize post-translational modifications (phosphoproteome, acetylome, and succynilome) on specific proteins and study their functional impact. Bacteria studied are mainly Gram negative (Pseudomonas aeruginosa and Acinetobacter baumannii). The team has several goals: the search for new strategies to control biofilms, the search for markers of adhesion state and the characterization of metabolic cascades involved in adhesion.

In the material field, the BRICS team is involved in research aimed at designing new antibiotic film material modifying, for example, their surface properties (functionalization by antibacterial peptides, physical treatments, etc.) or by conferring them controlled salting-out properties of therapeutic agents through their micro/nano-structuring. In collaboration with the SCC team, BRICS contributes to developing nano-vectors in order to target adherent bacteria.

The BRICS Team is a key player within the PISSARO Proteomics Platform that is now part of “High-tech Research Infrastructures for Life Sciences” HERACLES (https://heracles.univ-rouen.fr). In this context, the team develops in-house teaching and scientific expertise covering a wide range of fields, from bioinformatics to mass spectrometry.

More information

In the material field, the BRICS team is involved in research aimed at designing new antibiotic film material modifying, for example, their surface properties (functionalization by antibacterial peptides, physical treatments, etc.) or by conferring them controlled salting-out properties of therapeutic agents through their micro/nano-structuring.

In collaboration with the SCC Team, the research team contributes to developing nano vectors in order to target adherent bacteria.

Address

Laboratoire Polymères, Biopolymères, Surfaces,
UMR 6270 CNRS, Université de Rouen,
Bâtiment CURIB,
Place Emile Blondel,
F-76821 Mont Saint Aignan CEDEX

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